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Subsequent oral administration of radiolabeled zafirlukast to volunteers, urinary excretion accounts for roughly 10% from the dose and the remainder is excreted in feces. Zafirlukast is not detected in urine.Zafirlukast is extensively hepatically metabolized by an enzyme termed CYP2C9. Zafirlukast inhibits the action of CYP3A4, bringing about drug-